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Table 6 Serum RAAS levels in relation to different ACE2 SNPs among participants with or without T2D

From: Association of ACE2 variant rs4646188 with the risks of atrial fibrillation and cardioembolic stroke in Uygur patients with type 2 diabetes

ACE2 SNPs ACE (U/L) Renin (pg/mL) Ang I (ng/L)
  Non-T2D T2D P value Non-T2D T2D P value Non-T2D T2D P value
rs2074192          
CC 40.3 ± 13.3 40.1 ± 15.6 0.936 33.2 ± 24.6 44.1 ± 18.9 < 0.001 2.39 ± 0.84 2.68 ± 1.02 0.015
TT + CT 40.9 ± 8.1 43.0 ± 14.4 0.137 32.7 ± 24.1 47.4 ± 23.4 < 0.001 2.48 ± 0.85 2.68 ± 1.12 0.081
P value 0.656 0.118   0.868 0.189   0.389 0.995  
rs4240157          
CC + CT 38.9 ± 10.8 41.1 ± 15.4 0.243 34.5 ± 19.9 44.9 ± 21.4 0.001 2.37 ± 0.92 2.94 ± 0.97 < 0.001
TT 41.2 ± 10.2 41.9 ± 14.8 0.628 32.4 ± 25.5 46.5 ± 20.2 < 0.001 2.47 ± 0.82 2.47 ± 1.11 0.949
P value 0.117 0.682   0.501 0.539   0.449 < 0.001  
rs4646188          
CC + CT 41.5 ± 11.4 37.6 ± 17.0 0.113 33.7 ± 24.1 45.2 ± 20.7 0.002 2.43 ± 0.69 2.32 ± 1.00 0.450
TT 40.2 ± 9.7 42.7 ± 14.2 0.037 32.5 ± 24.4 45.9 ± 20.8 < 0.001 2.45 ± 0.93 2.79 ± 1.07 0.001
P value 0.306 0.017   0.704 0.814   0.788 0.002  
ACE2 SNPs Ang II (ng/L) ALD (ng/L)    
  Non-T2D T2D P value Non-T2D T2D P value    
rs2074192          
CC 116.6 ± 62.1 162.9 ± 55.0 < 0.001 243.1 ± 73.8 224.7 ± 101.1 0.105    
TT + CT 126.2 ± 81.3 135.1 ± 46.5 0.232 235.1 ± 82.5 276.9 ± 110.8 < 0.001    
P value 0.305 < 0.001   0.419 < 0.001     
rs4240157          
CC + CT 118.9 ± 65.6 168.7 ± 46.8 < 0.001 233.2 ± 83.2 259.9 ± 107.5 0.085    
TT 123.7 ± 77.2 132.6 ± 51.7 0.193 239.6 ± 78.1 243.8 ± 110.2 0.688    
P value 0.655 < 0.001   0.574 0.225     
rs4646188          
CC + CT 127.4 ± 85.5 117.5 ± 48.5 0.345 244.5 ± 76.4 222.2 ± 85.6 0.082    
TT 119.6 ± 67.2 158.3 ± 50.2 < 0.001 234.3 ± 80.9 259.9 ± 114.0 0.011    
P value 0.406 < 0.001   0.306 0.005     
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BMC Cardiovascular Disorders

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